Without grooming and care, your dog will look dull, the coat can tangle and at the extreme seriously affect the health of your dog.
You should groom (or pay a professional ) your dog regularly to reduce the amount of dander.
Clean any dog beds or other areas your dog uses, sweeping, and vacuuming will also help keep the dander levels down.
Vacuum cleaners for pet hair help remove allergens, and some can even groom the hair and dander right from your dog.